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Magritek to Present Paper at SMASH, the Small Molecule NMR Conference

September 10, 2013

Magritek, a leading provider of compact NMR and MRI instruments, will present a paper in the New Developments in NMR Methodology program on Wednesday 25th September. Dr Andrew Coy will discuss "Two-Dimensional NMR Spectroscopy on a Desktop Spectrometer."

The SMASH 2013 NMR Conference will be held in Santiago de Compostela, Spain from September 22nd - 25th, 2013. SMASH is a scientific meeting highlighting Small Molecule work. There is a broad focus on NMR applications in addition to other analytical technologies used for small molecule research. The meeting attracts leading spectroscopists in this field and provides an excellent networking opportunity for students and professionals bringing together cutting-edge science from Academia and Industry.

Magritek will be presenting a paper on "Two-Dimensional NMR Spectroscopy on a Desktop Spectrometer." It will be delivered by co-founder, Dr Andrew Coy.

Two-dimensional (2D) NMR spectroscopy is a general concept that enables chemical information to be encoded into a second dimension making use of spin-spin interactions like J-coupling. It is particularly useful to simplify 1D spectra with overlapping signals and to identify coupled chemical groups. While 2D NMR techniques are routinely used at high field, they are not exploited on benchtop NMR spectrometers. One of the main reasons for this is the high stability required to sample the data along the indirect dimension. Frequency or phase instabilities between scans result in stripes along the t1 direction also known as t1 noise. Furthermore, the acquisition of meaningful 2D spectra is only possible if the spectrometer provides enough resolution and high signal-to-noise, otherwise the acquisition time for a 2D spectrum can become excessively long.

In this work, Coy will demonstrate the performance of 2D NMR on the Spinsolve™ benchtop NMR spectrometer. The performance of J-resolved spectroscopy, correlation spectroscopy (COSY), and double quantum filtered (DQ-COSY) will be shown. The results presented here demonstrate that 2D NMR is of great assistance for benchtop NMR spectroscopy where the spectrum of small molecules may appear crowded due to the strong coupling limit.

To obtain full details of Magritek's Spinsolve benchtop NMR spectrometer and the full range of analytical products from Magritek, visit,